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Welcome to ZenklusenLab

Our laboratory studies the regulation of gene expression at the single cell level. Our main focus is to use microscopy to determine how individual cells execute and coordinate the different steps along the gene expression pathway, allowing the controlled expression of their genes. We therefore combine single molecule techniques and quantitative analysis methods with genetics and biochemistry to gain better understanding of the general rules governing the expression of genes in complex systems, using yeast and mammalian cell models.

We are particularly interested in two steps of the gene expression pathway, transcription regulation by non-coding RNAs and RNA transport/localization. Read More ...

Tracking mRNAs on their way to the cytoplasm

In our recent papers in the Journal of Cell Biology, we used real time particule tracking to show how mRNAs find their way to the cytoplasm.

Expanding the RNA imaging toolbox

Combing MS2 and PP7 RNA tags allows now for simultanous detection of multiple RNA species in living cells. Hocine, Raymond et al., nautre methods

News !

11-23-2016

Samir and Cornelia's eRNA paper accepted in NAR !

11-17-2016

Collaborative paper with the Rout, Sali and Chait labs published in Cell .

08-19-2016

New plasmids for PP7 tagging from Saroufim et al., JCB 2015 are now available on Addgene.

07-10-2016

Welcome Xuedong, MITACS student from Jilin University !

12-21-2015

'JCB - In Focus' on our papers : mRNAs scan themselves out .

12-21-2015

Mark-Albert's paper published in JCB .

09-21-2015

Daniel talking at Riboclub 2015 .

09-01-2015

Welcome Srivathsan !

05-06-2014

Congrats Samir for receiving the 'Simon-Pierre-Nöels' prize!

05-01-2014s

Welcome Denis, Samy and Kevin, the 2015 summer team.

03-13-2015

Cornelias's paper in PNAS is online.

12-15-2014

Congrats Mark-Albert for your Master thesis!

09-06-2014

Finally. Zenklusenlab Photo Stream is up.

04-01-2014

Welcome Pierre !

04-01-2014

Congratulation Sandra for completing your Master thesis.

03-10-2014

Daniel talking eRNAs at Long-Range Genome Organization and Transcription Dynamics conference at Janelia Farm.

01-15-2014

Welcome Shraddha

09-14-2013

Daniel at Stochasticity in Biochemical Reaction Networks workshop in Banff.

08-28-2013

Samir's methods chapter in Methods Mol Bio is online.

08-08-2013

Zenklusenlab plasmids now available on Addgene.

08-04-2013

Welcome Cornelia!

06-16-2013

Samir's paper published in nature structural & molecular biology - Bimodal expression of PHO84 is modulated by early termination of antisense transcription.

06-12-2013

Samir and Daniel at RNA 2013 in Davos, Switzerland.

05-23-2013

Regulating RNA turnover - Vincent's paper published in Cell A Nutrient-Responsive Pathway that Determines M Phase Timing through Control of B-Cyclin mRNA Stability

05-07-2013

Welcome Melissa and Emmanuel!

12-23-2012

Pascal's first paper published in Nature methods Single-molecule analysis of gene expression using two-color RNA labeling in live yeast

09-25-2012

EMBO | EMBL Symposium The Complex Life of mRNA Daniel's presenting Samirs project

09-25-2012

Riboclub meeting 2012 Congratulation Samir for winning a travel award!

09-17-2012

We are on TV! CBS-Explora

08-17-2012

Correntin and Michael are leaving. Good luck at Columbia/Medical school.

06-16-2012

Daniel presents Samirs data at the EMBO meeting: Gene Transcription in Yeast, from Mechanisms to Gene Regulatory Networks

05-15-2012

Summer sudents start. Welcome Frédérique, welcome back Zack!

03-05-2012

Check this out: Our MDN1 FISH image is the first picture that appears on the Saccharomyces genome database website! http://www.yeastgenome.org/

22-02-2012

mRNA export review is online. 'To the pore and through the pore: A story of mRNA export kinetics'

02-02-2012

Tatjana's FISH protocol is online in nature protocols. Single-mRNA counting using fluorescent in situ hybridization in budding yeast.

25-01-2012

The first parts of the new microscope are in :-)

05-01-2012

Happy New Year everyone

12-12-2011

New web site is up ! Thanks Sandrine !

Our lab

UdeM We are located at the Université de Montréal in the Département de Biochimie and are funded by the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council of Canada (NSERC), Fonds de recherche Santé Québec (FRSQ) and the Canada Foundation for Innovation (CFI).